Excipients

The Probiotic Problem Solver

Fujicalin (unique DCPA, dibasic calcium phosphate anhydrous, GRAS):

  • Significantly reduce probiotic die-off during tableting and prolong shelf life by improving product stability.
  • First viable opportunity to formulate probiotics into tablet.
  • Direct compression for easy in-house production.

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The Superior Adsorbent

As a superior adsorbent, Fujicalin allows to convert oily actives (such as vitamin E oil, fish oil) into flowable and compressible powder. Below is a study showing that Fujicalin is used to adsorb 13wt% of linseed oil into free flowing powder and further high quality tablets are made. On the other hand, severe agglomeration is observed by using conventional DCPA as an adsorbent.

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Fujicalin loaded with 13% of linseed oil
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Conventional DCPA loaded with 13% of linseed oil
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Fujicalin with 13% of linseed oil

Ready-To-Use ODT Base

  • Easy to use via a conventional tablet press
  • Very flowable with little or no sticking/capping
  • Excellent mouth feel
  • Oral disintegration time less than 30 seconds
  • High active loading achievable
  • No royalty or licensing fees required Prototype tablets and formulations are available:

Oral Dissolving: Melatonin, Vitamin B12, Vitamin C, Vitamin B complex, Probiotics

Chewable: CoQ10, Glucosamine/Chondroitin

Oral Dissolving F-MELT® Melatonin Tablets

3mg Melatonin + 10mg VB6

  • Rapid oral disintegrating tablets
  • No water required: pleasant mouth feel
  • Two great flavors: cherry and Orange

For technical or purchasing information regarding F-MELT® Melatonin Tablets, please contact Xi Han at han@fujichemicalusa.com

F-MELT®

A New Excipient for Fast Oral Dissolve Systems

  • Ready-to-use powder matrix
  • Oral disintegration time less than 30 seconds
  • High direct compressibility and easy to use
  • No royalty or licensing fees required
  • High API loading achievable
  • Very flowable with little or no sticking/capping

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Neusilin®

A Unique Form of Amorphous Magnesium Aluminometasilicate

  • Unique mesoporous carrier for solid dispersion
  • High direct compressibility
  • Accelerates disintegration
  • Can act as buffering agent
  • Dramatically improves flowability of most powders
  • Competent adsorbent for liquid and SMEDDS
  • Adsorbs up to 300% of its weight in oil or liquid actives

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Fujicalin®

A Unique Form of Spray Dried Dibasic Calcium Phosphate Anhydrous

  • Improves blend content uniformity even for micronized API with low loading
  • Exceptional flowability
  • Promotes rapid disintegration
  • High direct compressibility
  • High oil adsorption capability
  • Non-abrasive
  • The probiotic problem solver-significantly improves survivability during tableting & stability during storage

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